Cancer Biology

Tumour cells display several features that distinguish them from normal cells. The ability to divide uncontrolled arises as a consequence of malfunctions in the cells’ signal systems, but there are also physical differences in, for example, the cytoskeleton, the cell nucleus, and enzyme production.

As the cells become more and more abnormal they acquire new features, such as the ability to secrete growth factors and enzymes that destroy surrounding cells. A decisive step in the development of a tumour is the regeneration of blood vessels (angiogenesis) which provide the cancer cells with oxygen and nourishment.

LiU researchers are studying cell nuclear proteins such as linker histones, a family of basic proteins that are suspected to also play a role when tumours develop. Through analysing the interplay between linker histones and chromatin in the cell, scinetists hope to increase knowledge of the role of these molecules in cell growth, differentiation, and cell death.

Areas of Research

• Studies on Leukotriene C Synthase and Nuclear Eicosanoid Receptors (Link to Sven Hammarström¿s site) 
• The linker histones – subtypes and phosphorylation in cell cycle regulation (Link to Ingemar Rundquist’s site)