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Nilsson has published 59 papers. His publications have been cited over 1000 times. The most cited paper (Nature Materials 2003) has over 190 citations. H-index 22.

 

1. Articles in refereed scientific journals:

  1. Nilsson, K. P. R., Andersson, M. R., Inganäs, O. (2002) Conformational transitions of a free amino-acid-functionalized polythiophene induced by different buffer systems. J. Phys. Condens. Mat. 14, 10011-10020.

 

  1. Nilsson, K. P. R., Andersson, M. R., Inganäs, O. Conformational transitions of a free amino-acid-functionalized polythiophene. (2003) Synth. Met.  135, 291-292.

 

  1. Nilsson, K. P. R., Inganäs, O. (2003) Chip and solution detection of DNA hybridisation using a luminescent zwitter-ionic polythiophene derivative. Nature Materials 2, 419-424.

 

  1. Nilsson, K. P. R., Rydberg, J., Baltzer, L., Inganäs, O. (2003) Self-assembly of synthetic peptides control conformation and optical properties of a zwitterionic polythiophene derivative.  Proc. Natl. Acad. Sci. USA 100, 10170-10174.

 

  1. Nilsson, K. P. R., Rydberg, J., Baltzer, L., Inganäs, O. (2004) Twisting macromolecular chains – self-assembly of a chiral supermolecule from non-chiral polythiophene polyanions and random coil synthetic peptides. Proc. Natl. Acad. Sci. USA 101, 11197-11202.

 

  1. Nilsson, K. P. R., Olsson, J. D. M., Konradsson, P., Inganäs, O. (2004) Enantiomeric substituents determine the chirality of luminescent conjugated polythiophenes. Macromolecules 37, 6316-6321.

 

  1. Nilsson, K. P. R., Inganäs, O. (2004) Optical emission of a conjugated polyelectrolyte: Calcium-induced conformational changes in Calmodulin and Calmodulin-Calcineurin interactions. Macromolecules 37, 9109-9113.

 

  1. Åsberg, P., Nilsson, K. P. R., Inganäs, O. (2004) Fluorescence quenching and excitation transfer between semiconducting and metallic organic layers J. Appl. Physics 96, 3140-3147.

 

  1. Björk, P., Persson, N-K., Nilsson, K. P. R., Åsberg, P., Inganäs, O. (2004) Dynamics of complex formation between biological and luminescent conjugated polyelectrolytes—a surface plasmon resonance study. Biosensors and Bioelectronics 107, 1764-1771.

 

  1. Herland, A., Nilsson, K. P. R., Olsson, J. D. M., Konradsson, P., Hammarström, P., Inganäs, O. (2005) Synthesis of a regioregular zwitterionic conjugated oligoelectrolyte, usable as an optical probe for detection of amyloid fibrillation at acidic pH. J. Am. Chem. Soc. 127, 2317-2323.

 

  1. Nilsson, K. P. R., Herland, A., Hammarström, P., Inganäs, O. (2005) Conjugated polyelectrolytes – conformation sensitive optical probes for detection of amyloid fibril formation. Biochemistry 44, 3718-3724.

 

  1. Herland, A., Björk, P., Nilsson, K. P. R., Olsson, J. D. M., Åsberg, P., Konradsson, P., Hammarström, P., Inganäs, O. (2005) Electroactive Luminescent Self-assembled Bio-organic Nanowires. Adv. Mater. 17, 1466-1471.

 

  1. Karlsson, F. K., Åsberg, P., Nilsson, K. P. R., Inganäs, O. (2005) Interactions between a zwitterionic polythiophene derivative and oligonucleotides as resolved by fluorescence resonance energy transfer. Chem. Mat. 17, 4204-4211.

 

  1. Nilsson, K. P. R., Olsson, J. D. M., Stabo-Eeg, F., Lindgren, M., Konradsson, P., Inganäs, O. (2005) Chiral recognition of a synthetic peptide using enantiomeric conjugated polyelectrolytes and optical spectroscopy. Macromolecules 38, 6813-6821.

 

  1. Nilsson, K. P. R., Lovelace, E. S., Caesar, C. E., Tynngard, N., Alewood, P. F., Johansson, H. M., Sharpe, I. A., Lewis, R. J., Daly, N. L., Craik, D. J. (2005) Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter. Biopolymers 80, 815-823.

 

  1. Filippini, D., Åsberg, P., Nilsson, P., Inganäs, O., Lundström, I. (2005) Computer screen photo-assisted detection of complementary DNA strands using a luminescent zwitterionic polythiophene derivative. Sensors and Actuators B: Chemica, 113, 410-418.

 

  1. Åsberg, P., Nilsson K. P. R., Inganäs O. (2006) Surface energy modified chips for detection of conformational states and enzymatic activity in biomolecules. Langmuir 22, 2205-2211.

 

  1. Nilsson, K. P. R., Hammarström, P., Ahlgren, F., Herland, A., Schnell, E. A., Lindgren, M., Westermark, G. T., Inganäs, O. (2006) Conjugated polyelectrolytes - Conformation-sensitive optical probes for staining and characterization of amyloid deposits. Chembiochem. 7, 1096-1104.

 

  1. Björk, P., Nilsson, K. P. R., Lenner, L., Kågedal, B., Persson, B., Inganäs, O., Jonasson, J. (2007) Conjugated polythiophene probes target lysosome-related acidic vacuoles in cultured primary cells. Mol. Cell. Probes. 5-6, 329-337.

 

  1. Stabo-Eeg, F., Lindgren, M., Nilsson, K. P. R., Inganäs, O., Hammarström, P. (2007) Quantum efficiency and two-photon absorption cross-section of conjugated polyelectrolytes used for protein conformation measurements with applications on amyloid structures. Chem. Phys.   336, 121-126.

 

  1. Nilsson, K. P. R., Åslund, A., Berg, I., Nyström, S., Konradsson, P., Inganäs, O., Stabo-Eeg, F., Lindgren, M., Westermark, G.T., Lannfelt, L., Nilsson, L.N., Hammarström, P.  (2007) Imaging distinct conformational states of amyloid-beta fibrils in Alzheimer's disease using novel luminescent probes. ACS Chem. Biol. 2, 553-560.

 

  1. Åslund, A., Herland, A., Hammarström, P., Nilsson, K. P. R., Jonsson, B.H., Inganäs, O., Konradsson, P. (2007) Studies of luminescent conjugated polythiophene derivatives: enhanced spectral discrimination of protein conformational states. Bioconjug. Chem. 6, 1860-1868.

 

  1. Sigurdson, C.J, Nilsson, K.P.R., Hornemann, S., Manco, G., Polymenidou, M., Schwarz, P., Leclerc, M., Hammarström, P, Wüthrich, K., Aguzzi, A. (2007) Prion strain discrimination using luminescent conjugated polymers. Nature Methods 12, 1023-1030.

 

  1. Nilsson, K.P.R., Hammarström, P. (2008) Luminescent conjugated polymers: Illuminating the dark matters of biology and pathology. Adv. Mater. 12,   2639-2645.

 

  1. Falsig, J., Nilsson K. P. R., Knowles, T. P. J., Adriano Aguzzi. (2008) Chemical and biophysical insights into the propagation of prion strains. HFSP JOURNAL 2, 332-341.

 

  1. Philipson, O., Hammarström, P., Nilsson, K.P.R., Portelius, E., Olofsson, T., Ingelsson, M., Hyman, B.T., Blennow, K., Lannfelt, L., Kalimo, H., Nilsson, L.N. (2008) A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice. Neurobiol. Aging. 30, 1393-1405.

 

  1. Sigurdson, C. J., Nilsson, K. P. R., Hornemann, S., Heikenwalder, M., Manco, G., Schwarz, P., Ott, D., Rülicke, T., Liberski, P. P., Julius, C., Falsig, J., Stitz, L., Wüthrich, K., Aguzzi, A. (2009) De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis. Proc. Natl. Acad. Sci. USA 106, 304-309.

 

  1. Nilsson, K. P. R. (2009) Small organic probes as amyloid specific ligands - Past and recent molecular scaffolds. FEBS Lett. 583, 2593-2599.

 

  1. Maji, S. K., Perrin, M. H., Sawaya, M. R., Jessberger, S., Vadodaria, K., Rissman, R. A., Singru, P. S., Nilsson, K. P. R., Simon, R., Schubert, D., Eisenberg, D., Rivier, J., Sawchenko, P., Vale, W., Riek R. (2009) Functional Amyloids as Natural Storage of Peptide Hormones in Pituitary Secretory Granules. Science 325, 328-332.

 

  1. Åslund, A., Sigurdson, C. J., Klingstedt, T., Grathwohl, S., Bolmont, T., Dickstein, D. L., Glimsdal, E., Prokop, S., Lindgren, M., Konradsson, P., Holtzman, D. M., Hof, P. R., Heppner, F. L., Gandy, S., Jucker, M., Aguzzi, A., Hammarström, P., Nilsson, K. P. R. (2009) Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. ACS Chem. Biol. 4, 673-684.

 

  1. Åslund A, Nilsson, K. P. R., Konradsson P. (2009) Fluorescent oligo and poly-thiophenes and their utilization for recording biological events of diverse origin-when organic chemistry meets biology. J. Chem. Biol. 2, 161-175.

 

  1. Almstedt, K., Nyström, S., Nilsson, K. P. R., Hammarström, P. (2009) Amyloid fibrils of human prion protein are spun and woven from morphologically disordered aggregates. Prion 3, 224-235.

 

  1. Nilsson, K. P. R., Ikenberg, K., Aslund, Å, Fransson, S., Konradsson, P., Röcken, C., Moch, H., Aguzzi, A. (2010) Structural typing of systemic amyloidoses by luminescent-conjugated polymer spectroscopy. Am. J. Pathol. 176, 563-574.

 

  1. Berg, I., Nilsson, K. P. R., Thor, S., Hammarström, P. (2010) Efficient imaging of amyloid deposits in Drosophila models of human amyloidoses. Nature Protocols 5, 935-944.

 

  1. Sigurdson, C. J., Nilsson, K. P. R., Hornemann, S., Manco, G., Fernández-Borges, N., Schwarz, P., Castilla, J., Wüthrich, K., Aguzzi, A. (2010) A molecular switch controls interspecies prion disease transmission in mice. J Clin Invest. 120, 2590-2599.

 

  1. Ostapchenko, V. G., Sawaya, M. R., Makarava, N., Savtchenko, R., Nilsson, K. P. R., Eisenberg, D., Baskakov, I. V. (2010) Two amyloid States of the prion protein display significantly different folding patterns.  J Mol Biol. 400, 908-921.

 

  1. Hammarström, P., Simon, R., Nyström, S., Konradsson, P., Åslund, A., Nilsson, K. P. R. (2010) A fluorescent pentameric thiophene derivative detects in vitro-formed prefibrillar protein aggregates. Biochemistry. 49, 6838-6845.

 

  1. Gabrielsson, E. O., Tybrandt, K., Hammarström, P., Berggren, M., Nilsson, K. P. R. (2010) Spatially Controlled Amyloid Reactions Using Organic Electronics. Small. 6, 2153-2161.

 

  1. Nilsson, K. P. R., Joshi-Barr, S., Winson, O., Sigurdson, C. J. (2010) Prion strain interactions are highly selective. J Neurosci. 30, 12094-12102.

 

  1. Lindgren, M., Glimsdal, E., Åslund, A., Simon, R., Hammarström, P., Nilsson, K. P. R. (2010) Luminescence and Two-Photon Absorption Cross Section of Novel Oligomeric Luminescent Conjugated Polythiophenes for Diagnostics of Amyloid Fibrils. Nonlinear Optics Quantum Optics 40, 241-251.

 

  1. Klingstedt, T., Nilsson, K. P. R. (2011) Conjugated polymers for enhanced bioimaging. Biochim Biophys Acta. 1810, 286-296.

 

  1. Lord, A., Philipson, O., Klingstedt, T., Westermark, G. T., Hammarström, P., Nilsson, K. P. R., Nilsson, L. N. G. (2011) Observations in APP Bitransgenic Mice Suggest that Diffuse and Compact Plaques Form via Independent Processes in Alzheimer's Disease. Am. J. Pathol. 178, 2286-2298.

 

  1. Sigurdson C. J., Bartz, J. C., Nilsson, K. P. R. (2011) Tracking protein aggregate interactions.  Prion 5, 52-55.

 

  1. Schultz, S. W., Nilsson, K. P. R., Westermark, G. T. (2011) Drosophila Melanogaster as a Model System for Studies of Islet Amyloid Polypeptide Aggregation. PLoS One 6, e20221.

 

  1. Mahajan, V., Klingstedt, T., Simon, R., Nilsson, K. P. R., Thueringer, A., Kashofer, K., Haybaeck, J., Denk, H., Abuja, P. M., Zatloukal, K. (2011) Cross β-sheet conformation of keratin 8 is a specific feature of Mallory-Denk bodies compared with other hepatocyte inclusions. Gastroenterology 141, 1080-1090.

 

  1. Sigurdson, C. J., Joshi-Barr, S., Bett, C., Winson, O., Manco, G., Schwarz, P., Rülicke, T., Nilsson, K. P. R., Margalith, I., Raeber, A., Peretz, D., Hornemann, S., Wüthrich, K., Aguzzi, A. (2011) Spongiform encephalopathy in transgenic mice expressing a point mutation in the β2-α2 loop of the prion protein. J. Neurosci. 31, 13840-13847.

 

  1. Klingstedt, T., Åslund, A., Simon, R. A., Johansson, L. B. G., Mason, J. J., Nyström, S., Hammarström, P., Nilsson K. P. R. (2011) Synthesis of a library of oligothiophenes and their utilization as fluorescent ligands for spectral assignment of protein aggregates. Org. Biomol. Chem. 9, 8356-8370.

 

  1. Zako, T., Sakono, M., Kobayashi, T., Sörgjerd, K., Nilsson, K. P. R., Hammarström, P., Lindgren, M., Maeda, M. (2012) Cell Interaction Study of Amyloid by Using Luminescent Conjugated Polythiophene: Implication that Amyloid Cytotoxicity Is Correlated with Prolonged Cellular Binding. ChemBioChem, 13, 358-363.

 

  1. Psonka-Antonczyk, K. M., Duboisset, J., Stokke, B. J., Zako, T., Kobayashi, T., Maeda, M., Nyström, S., Mason, J., Hammarström, P., Nilsson, K. P. R., Lindgren, M. (2012) Nanoscopic and Photonic Ultrastructural Characterization of Two Distinct Insulin Amyloid States. Int. J. Mol. Sci., 13, 1461-1480.

 

  1. Caesar, I., Jonson, M., Nilsson, K. P. R., Thor, S., Hammarström, P. (2012) Curcumin Promotes A-beta Fibrillation and Reduces Neurotoxicity in Transgenic Drosophila. PLoS One, 7, e31424.

 

  1. Göransson, A. L., Nilsson, K. P. R., Kågedal, K., Brorsson, A. C. (2012) Identification of distinct physiochemical properties of toxic prefibrillar species formed by Aβ peptide variants. Biochem Biophys Res Commun. 420, 895-900.

 

  1. Margalith, I., Suter, C., Ballmer, B., Schwarz, P., Tiberi, C., Sonati, T., Falsig, J., Nyström, S., Hammarström, P., Åslund, A., Nilsson, K. P. R., Yam, A., Whitters, E., Hornemann, S., Aguzzi, A. (2012) Polythiophenes inhibit prion propagation by stabilizing PrP aggregates. J. Biol Chem. 287, 18872-18887.

 

  1. Nilsson, K. P. R., Lindgren, M., Hammarström, P. (2012) A pentameric luminescent-conjugated oligothiophene for optical imaging of in vitro-formed amyloid fibrils and protein aggregates in tissue sections. Methods Mol Biol. 849, 425-434.

 

  1. Bett, C., Fernández-Borges, N., Kurt, T. D., Lucero, M., Nilsson, K. P. R., Castilla, J., Sigurdson, C. J. (2012) Structure of the β2-α2 loop and interspecies prion transmission. FASEB J. Apr 9. [Epub ahead of print]

 

  1. Fyrner, T., Magnusson, K., Nilsson, K. P. R., Hammarström, P., Aili, D., Konradsson, P. (2012) Derivatization of a Bioorthogonal Protected Trisaccharide Linker-Toward Multimodal Tools for Chemical Biology. Bioconjug Chem. Jun 5. [Epub ahead of print]

 

  1. Nyström, S., Mishra, R., Hornemann, S., Aguzzi, A., Nilsson, K. P. R., Hammarström, P. Multiple substitutions of methionine 129 in human prion protein reveal its importance in the amyloid fibrillation pathway. J Biol Chem. Jun 5. [Epub ahead of print]

 

  1. Luminescent conjugated poly- and oligo-thiophenes: optical ligands for spectral assignment of a plethora of protein aggregates. Klingstedt T, Nilsson KPR. Biochem Soc Trans. 2012 Aug 1;40(4):704-10.

 

  1. Spectral discrimination of cerebral amyloid lesions after peripheral application of luminescent conjugated oligothiophenes. Bettina M. Wegenast-­Braun, Angelos Skodras, Gonca Bayraktar, Jasmin Mahler, Sarah K. Fritschi, Therése Klingstedt, Jeffrey J. Mason, Per Hammarström, KPR Nilsson, Christian Liebig, Mathias Jucker. Accepted in American Journal of pathology 2012

 

  1. Localization of Cholesterol, Amyloid and Glia in Alzheimer's Disease Transgenic´Mouse Brain Tissue Using Time-of-Flight Secondary Ion Mass Spectrometry (ToFSIMS) and Immunofluorescence Imaging. Santiago Solé-Domènech, Peter Sjövall, Vladana Vukojević, Ruani Fernando, Alina Codita, Sachin Salve, Nenad Bogdanović, Abdul H. Mohammed, Per Hammarström, K. Peter R. Nilsson, Frank M. LaFerla, Stefan Jacob, Per-Olof Berggren, Lydia Giménez-Llort, Martin Schalling, Lars Terenius and Björn Johansson. Accepted in Acta Neuropathologica 2012

 

 

 

2. Book chapters              

 

  • Optical sensors based on conjugated polymers. Authors: K. Peter. R. Nilsson and Olle Inganäs. Chapter 13 in Handbook of Conducting Polymers (Third Edition 2007)

 

  • Conjugated Polyelectrolytes for Staining and Characterization of Amyloid Deposits. Author: K. Peter R. Nilsson. Chapter 16 in Organic Electronics in Sensors and Biotechnology (First Edition 2009) by Ruth Shinar and Joseph Shinar.

 

  • Optical Reporting by Conjugated Polymers via Conformational Changes. Authors: Rozalyn A. Simon and K. Peter R. Nilsson. Chapter 13 in Springers serie on Fluorescence Volume 9 of “Advanced Fluorescence Reporters in Chemistry and Biology II” edited by Alexander P. Demchenko (Springer 2010)

 

  • A Pentameric Luminescent-Conjugated Oligothiophene for Optical Imaging of In Vitro-Formed Amyloid Fibrils and Protein Aggregates in Tissue Sections. Authors: K. Peter. R. Nilsson, Mikael Lindgren and Per Hammarström. Chapter 29 in Amyloid Proteins: Methods and Protocols (Springer Second Edition 2012)

 

 

3. Patent applications

 

  • Polyelectrolyte complex (e.g. zwitterionic polythiophenes) with a receptor (e.g. polynucleotide, antibody etc.) for biosensor applications. Inventors: Inganäs, O., Nilsson, P., Åsberg, P.
  • Methods for determine conformational changes and self-assembly of proteins. Inventors: Nilsson, P., Herland, A., Hammarström, P., Åsberg, P., Inganäs, O.
  • Methods using self-assembly/aggregation of biomolecules for the construction of electronic devices based on conjugated polymers. Inventors: Nilsson, P., Herland, A., Hammarström, P., Björk, P., Inganäs, O.
  • Patterning method for biosensor applications and devices comprising such patterns. Inventors: Åsberg, P., Nilsson, P., Inganäs, O.
  • Methods for detection of pathogenic prion proteins associated with prion diseases, using conjugated polyelectrolytes. Inventors: Nilsson, P., Hammarström, P.
  • Novel thiophene derivatives. Inventors: Nilsson, P., Åslund, A., Konradsson, P., Åsberg, P., Johansson, L., Herland, A.
  • Oligothiophene derivatives as molecular probes. Inventors: Hermanson, O., Konradsson, P. Åslund, A., Simon, R., Ilkhanizadeh, S., Nilsson P.

Page responsible: peter.r.nilsson@liu.se
Last updated: Thu Oct 25 15:07:02 CEST 2012