Publications

Publications of David Engblom in DiVA (publication database)

Original articles

• Parkitna JR, Sikora M, Gołda S, Gołembiowska K, Bystrowska B, Engblom D, Bilbao A, Przewłocki R. (2013) Novelty-seeking behaviors and the escalation of alcohol drinking after abstinence in mice are controlled by mGluR5 receptors on neurons expressing dopamine D1 receptors. Biol Psychiatry. 73, 263-70
• Engström L, Ruud J, Eskilsson A, Larsson A, Mackerlova L, Kugelberg U, Qian H, Vasilache AM, Larsson P, Engblom D, Sigvardsson M, Jönsson JI, Blomqvist A. (2013) Lipopolysaccharide-Induced Fever Depends on Prostaglandin E2 Production Specifically in Brain Endothelial Cells. Endocrinology. 153, 4849-62
• Ruud J, Nilsson A, Engström Ruud L, Wang W, Nilsberth C, Iresjö BM, Lundholm K, Engblom D, Blomqvist A. (2013) Cancer-induced anorexia in tumor-bearing mice is dependent on cyclooxygenase-1. Brain Behav Immun. 29, 124-35
• Ruud J, Wilhelms DB, Nilsson A, Eskilsson A, Tang YJ, Ströhle P, Caesar R, Schwaninger M, Wunderlich T, Bäckhed F, Engblom D, Blomqvist A. (2013) Inflammation- and tumor-induced anorexia and weight loss require MyD88 in hematopoietic/myeloid cells but not in brain endothelial or neural cells. FASEB J. In Press; PMID: 23395911
• Ruud LE, Wilhelms DB, Eskilsson A, Vasilache AM, Elander L, Engblom D, Blomqvist A. (2013) Acetaminophen reduces lipopolysaccharide-induced fever by inhibiting cyclooxygenase-2. Neuropharmacology, epub ahead of print
• Engblom D, Ek M, Hallbeck M, Ericsson-Dahlstrand A, Blomqvist A. (2000) Distribution of prostaglandin EP3 and EP4 receptor mRNA in the rat parabrachial nucleus. Neurosci Lett 281, 163-6.
• Ek M, Engblom D, Saha S, Blomqvist A, Jakobsson P-J, Ericsson-Dahlstrand A. (2001) Pathway across the blood-brain barrier. Nature 22;410, 430-1.
• Paues J, Engblom D, Mackerlova L, Ericsson-Dahlstrand A, Blomqvist A. (2001) Feeding-related immune responsive brain stem neurons: association with CGRP. Neuroreport 8, 2399-403.
• Engblom D, Ek M, Ericsson-Dahlstrand A, Blomqvist A. (2001) Activation of prostanoid EP3 and EP4 receptor messenger RNA expressing neurons in the rat parabrachial nucleus by intravenous injection of bacterial wall lipopolysaccharide. J Comp Neurol 440, 378-86.
• Engström L, Engblom D, Örtegren U, Mackerlova L, Paues J, Blomqvist A. (2001) Preproenkephalin mRNA expression in rat parabrachial neurons activated by intravenous lipopolysaccharide administration. Neurosci Lett 316, 165-8.
• Engblom D, Ek M, Andersson I, Dahlström M, Saha S, Jakobsson P-J, Ericsson-Dahlstrand A, Blomqvist A. (2002) Induction of microsomal prostaglandin E synthase in the rat brain endothelium and parenchyma in adjuvant-induced arthritis. J Comp Neurol 452, 205-14.
• Nilsson S, Scheike M, Engblom D, Karlsson LG, Mölstad S, Åkerlind I, Örtoft K, Nylander E. (2003) Chest pain and ischemic heart disease in primary care. Br J Gen Pract, 53(490), 378-82.
• Söderström M, Engblom D, Blomqvist A and Hammarström S. (2003) Expression of leukotriene C4 synthase mRNA by the choroid plexus in mouse brain suggests novel neurohormone functions of cysteinyl leukotrienes. Biochem Biophys Res Commun. 307, 987-90.
• Engström L, Engblom D, and Blomqvist A. (2003) Systemic immune challenge induces preproenkephalin gene transcription in distinct autonomic structures of the rat brain. J Comp Neurol, 462, 450-61
• Engblom D, Saha S, Engström L, Westman M, Audoly L P, Jakobsson J, Blomqvist A. (2003) Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis. Nat Neurosci, 6, 1137-38.
• Engblom D, Ek M, Ericsson-Dahlstrand A, Blomqvist A. (2004) Neuropeptide content of prostaglandin EP3 and EP4 receptor mRNA expressing neurons in the rat parabrachial nucleus. Neuroscience, 126, 989-99.
• Richard S, Engblom D, Paues J, Mackerlova L, Blomqvist A. (2004) Activation of the parabrachio-amygdaloid pathway by immune challenge and nociceptive stimulation: a quantitative study in the rat using Fos immunohistochemistry and retrograde tract tracing. J Comp Neurol, 481, 210-19.
• Engblom D, Kornfeld J-W, Schwake L, Tronche F, Reimann A, Beug H, Hennighausen L, Moriggl R and Schütz G. (2007) Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression. Genes Dev, 21, 1157-62.
• Engström L, Rosén K, Angel A, Fyrberg A, Mackerlova L, Pieter Konsman J, Engblom D, Blomqvist A (2008) Systemic immune challenge activates an intrinsically regulated local inflammatory circuit in the adrenal gland. Endocrinology, 149, 1436-50
• Lemberger T, Rodriguez Parkitna J, Chai M, Schütz G, Engblom D. (2008) CREB has a context-dependent role in activity-regulated transcription and maintains neuronal cholesterol homeostasis. FASEB J, 22, 2872-9.
• Engblom D, Bilbao A, Sanchis-Segura C, Dahan L, Perreau-Lenz S, Balland B, Rodriguez Parkitna J, Lujan R, Halbout B, Mameli M, Parlato R, Sprengel R, Lüscher C, Schütz G, Spanagel R. (2008) Glutamate receptors on dopaminergic neurons control the persistence of drug-seeking. Neuron, 59, 497-508.
• Bilbao A, Rodriguez Parkitna J, Engblom D, Perreau-Lenz S, Sanchis-Segura C, Schneider M, Konopka W, Westphal M, Breen G, Desrivieres S, Klugmann M, Bading H, Rodriguez de Fonseca F, Guindalini C, Vallada H, Laranjeira R, Schumann G, Schütz G, Spanagel R. (2008) Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine. Proc Natl Acad Sci U S A, 105, 17549-54.
• Elander L, Engström L, Ruud J, Mackerlova L, Jakobsson P-J, Engblom D, Nilsberth C, Blomqvist A. (2009) Inducible prostaglandin E2 synthesis interacts in a temporally supplementary sequence with constitutive prostaglandin synthesizing enzymes in creating the HPA-axis response to immune challenge. J Neurosci, 29, 1404-13.
• Mameli M, Halbout B, Creton C, Engblom D, Rodriguez Parkitna J, Spanagel R, Luscher C. (2009) Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. Nat Neurosci, 12, 1036-41.
• Ruud J, Bäckhed F, Engblom D, Blomqvist A. (2010) Deletion of the gene encoding MyD88 protects from anorexia in a mouse tumor model. Brain Behav Immun 24, 554-7.
• Rodriguez J, Bilbao A, Rieker C, Engblom D, Piechota M, Nordheim A, Spanagel R, Schütz G. (2010) Loss of the serum response factor in the dopamine system leads to hyperactivity. FASEB J, 24, 2427-35.
• Novak M, Halbout B, O’Connor E, Rodriguez J, Su T, Chai M, Crombag H, Bilbao A, Spanagel R, Stephens DN, Schütz G, Engblom D. (2010) Incentive learning underlying cocaine relapse requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons. J Neurosci, 30, 11973-82.
• Rieker C, Engblom D, Kreiner G, Domanskyi A, Schober A, Stotz S, Neumann M, Yuan X, Grummt I, Schütz G, Parlato R. (2011) Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of rapamycin signaling. J Neurosci, 31, 453-60.
• Van Bogaert T, Vandevyver S, Dejager L, Van Hauwermeiren F, Pinheiro I, Petta I, Engblom D, Kleyman A, Schutz G, Tuckermann J, Libert C. (2011) TNF inhibits glucocorticoid receptor function in mice: A strong signal towards lethal shock.  J Biol Chem, 286, 26555-67.
• Kornfeld JW, Mueller KM, Friedbichler K, Blaas L, Egger G, Esterbauer H, Hasselblatt P, Wagner KU, Engblom D, Haemmerle G, Kratky D, Sexl V, Kenner L, Terracciano L, Zechner R, Schuetz G, Casanova E Pospisilik, JA, Heim MH, Moriggl R (2011) Impairment of Hepatic Growth Hormone and Glucocorticoid Receptor Signaling Causes Steatosis and Hepatocellular Carcinoma in Mice. Hepatology, doi: 10.1002/hep.24509.
• Hagbom M, Istrate C, Engblom D, Karlsson T, Rodriguez-Diaz J, Buesa J, Taylor JA, Loitto VM, Magnusson KE, Ahlman H, Lundgren O, Svensson L. (2011) Rotavirus stimulates release of serotonin (5-HT) from human enterochromaffin cells and activates brain structures involved in nausea and vomiting. PLoS Pathog, Jul;7(7):e1002115
• Refojo D, Schweitzer M, Kuehne C, Ehrenberg S, Thoeringer C, Vogl AM, Dedic N, Schumacher M, von Wolff G, Avrabos C, Touma C, Engblom D, Schütz G, Nave KA, Eder M, Wotjak CT, Sillaber I, Holsboer F, Wurst W, Deussing JM. (2011) Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1. Science 333 (1903-7)
• Parkitna JR, Sikora M, Gołda S, Gołembiowska K, Bystrowska B, Engblom D, Bilbao A, Przewłocki R. (2013) Novelty-seeking behaviors and the escalation of alcohol drinking after abstinence in mice are controlled by mGluR5 receptors on neurons expressing dopamine D1 receptors. Biol Psychiatry. 73, 263-70
• Engström L, Ruud J, Eskilsson A, Larsson A, Mackerlova L, Kugelberg U, Qian H, Vasilache AM, Larsson P, Engblom D, Sigvardsson M, Jönsson JI, Blomqvist A. (2013) Lipopolysaccharide-Induced Fever Depends on Prostaglandin E2 Production Specifically in Brain Endothelial Cells. Endocrinology. 153, 4849-62
• Ruud J, Nilsson A, Engström Ruud L, Wang W, Nilsberth C, Iresjö BM, Lundholm K, Engblom D, Blomqvist A. (2013) Cancer-induced anorexia in tumor-bearing mice is dependent on cyclooxygenase-1. Brain Behav Immun. 29, 124-35
• Ruud J, Wilhelms DB, Nilsson A, Eskilsson A, Tang YJ, Ströhle P, Caesar R, Schwaninger M, Wunderlich T, Bäckhed F, Engblom D, Blomqvist A. (2013) Inflammation- and tumor-induced anorexia and weight loss require MyD88 in hematopoietic/myeloid cells but not in brain endothelial or neural cells. FASEB J. In Press; PMID: 23395911
• Ruud LE, Wilhelms DB, Eskilsson A, Vasilache AM, Elander L, Engblom D, Blomqvist A. (2013) Acetaminophen reduces lipopolysaccharide-induced fever by inhibiting cyclooxygenase-2. Neuropharmacology, epub ahead of print

Review articles and book chapter

• Engblom D, Ek M, Saha S, Ericsson-Dahlstrand, Jakobsson P-J, A Blomqvist A. (2002) Prostaglandins as inflammatory messengers across the blood-brain barrier. J Mol Med 80, 5-15
• Jakobsson P-J, Engblom D, Ericsson-Dahlstrand A, Blomqvist A. (2003) Microsomal prostaglandin E synthase: a key enzyme in PGE2 biosynthesis and inflammation. Cur Med Chem; Anti-inflamm & Anti-allergy agents 1, 167-175.
• Rodriguez Parkitna J. M, Engblom D, Schütz G. (2007) Generation of Cre recombinase expressing transgenic mice using bacterial artificial chromosomes. Methods Mol Biol, 530, 1-18.

• Parkitna JR, Engblom D (2012) Addictive drugs and plasticity of glutamatergic synapses on dopaminergic neurons: what have we learned from genetic mouse models? Frontiers in Molecular Neuroscience 5:89